After paying the toll, take Route 22 East to Route 309 South.  309 South becomes I-78 East.  Exit I-78 at Lehigh Street.  Turn left off the ramp onto Lehigh Street (north).  Continue to the second traffic light, Downyflake Lane.  Turn right onto Downyflake Lane.  The 2166 building is directly after the People's First Credit Union on the left-hand side.  The building is marked with the sign "Lehigh Valley Hospital and Health Network".  Turn left into the parking lot.  Parking is in the rear of the building.  Enter the building at the glass doors.  The GEM-Emergency Medicine Institute is located on the ground floor or basement of the building.

From Quakertown:

Route 309 North.  Route 309 North becomes I-78 West.  Exit I-78 at Lehigh Street.  Bear right onto Lehigh Street (north).  Continue to the next stoplight, Downyflake Lane.  Turn right onto Downyflake Lane.  The 2166 building is directly after the People's First Credit Union on the left-hand side.  The building is marked with the sign "Lehigh Valley Hospital and Health Network".  Turn left into the parking lot.  Parking is in the rear of the building.  Enter the building at the glass doors.  The GEM-Emergency Medicine Institute is located on the ground floor or basement of the building.

From Northern Bethlehem or Pocono's

Route 22 West to Route 309 South.  309 South becomes I-78 East.  Exit I-78 at Lehigh Street.  Turn left off the ramp onto Lehigh Street (north).  Continue to the second traffic light, Downyflake Lane.  Turn right onto Downyflake Lane.  The 2166 building is directly after the People's First Credit Union on the left-hand side.  The building is marked with the sign "Lehigh Valley Hospital and Health Network".  Turn left into the parking lot.  Parking is in the rear of the building.  Enter the building at the glass doors.  The GEM-Emergency Medicine Institute is located on the ground floor or basement of the building.

From Bethlehem, Easton, Pocono's via Route 33:

Route 33 South to I-78 West.  Exit I-78 at Lehigh Street.  Bear right onto Lehigh Street (North).  Continue to the next stoplight, Downyflake Lane.  Turn right onto Downyflake Lane. The 2166 building is directly after the People's First Credit Union on the left-hand side.  The building is marked with the sign "Lehigh Valley Hospital and Health Network".  Turn left into the parking lot.  Parking is in the rear of the building.  Enter the building at the glass doors.  The GEM-Emergency Medicine Institute is located on the ground floor or basement of the building.